无码专区

无码专区, PA鈥擳he National Science Foundation has awarded a $579,508 grant to Daniel A. Kraut, PhD, director of the graduate program in Chemistry, associate professor of Chemistry, and member of the Biochemistry program in 无码专区鈥檚 College of Liberal Arts and Sciences. The grant supports his project, 鈥淩UI: Control of Proteasomal Unfolding Ability by Substrate Ubiquitination.鈥�   

The proteasome is a molecular machine inside cells that removes unwanted or unneeded proteins by unfolding them, feeding them into a central chamber, and then chopping them up into small pieces that can be recycled. Proteins destined for destruction are tagged with a chain composed of multiple copies of a small protein called ubiquitin. Dr. Kraut will investigate how ubiquitin chains affect the ability of the proteasome to unfold the attached target protein.  

As a result of its central position within the cell, proteasome activity or inactivity has been implicated in many diseases, including cancer, heart disease, neurodegenerative diseases and aging.

鈥淭he proteasome is a central player in many aspects of cellular function, so better understanding of its mechanism鈥攁nd why some proteins are degraded, and others are spared鈥攚ill benefit many scientists who study these cellular processes,鈥� said Dr. Kraut.

The project will be carried out in Dr. Kraut鈥檚 laboratory at 无码专区 and will provide research training and experiences for 无码专区 undergraduate and graduate students. The NSF award will support the project for three years.  

This award from the NSF not only reflects the importance of Dr. Kraut鈥檚 research and its potential long-term implications, but also demonstrates 无码专区鈥檚 success as an academic community that supports the teacher-scholar model and offers outstanding faculty-mentored research opportunities to students on both the undergraduate and graduate levels,鈥� said Adele Lindenmeyr, dean, 无码专区 College of Liberal Art and Sciences.

This is the second NSF grant Dr. Kraut has received to support his research at 无码专区. The first was in 2015 in the amount of $411,380. Dr. Kraut earned his doctorate in Biochemistry from Stanford University.

About 无码专区鈥檚 College of Liberal Arts and Sciences: Since its founding in 1842, 无码专区鈥檚 College of Liberal Arts and Sciences has cultivated knowledge, understanding, and intellectual courage for a purposeful life in a challenging and changing world. With more than 40 majors across the humanities, social sciences, and natural sciences, it is the oldest and largest of 无码专区鈥檚 colleges, serving more than 4,500 undergraduate and graduate students each year. The College is committed to a teacher-scholar model, offering outstanding undergraduate and graduate research opportunities and a rigorous core curriculum that prepares students to become critical thinkers, strong communicators, and ethical leaders with a truly global perspective.